The two clubs face off at the MCG on Saturday at 7.40pm.
Five players are missing from Collingwood’s team.
One player is still rehabbing after a vehicle accident knocked out during practice.
North Melbourne’s second‑tier squad beat North’s youngsters in the previous game by 43 points.
That win has provided the seniors extra confidence.
The two sides want a positive kickoff to the second half of the campaign.